Share page
Faculty of Medicine :
Chair of Biophysics
In order to fill a fixed-term position in part-time (25,89 hours/week = 65%) at the earliest possible date or by August 01/2026, we are looking for 1
Researcher/PhD (m/f/x) for Medicinal Biophysics
The Karges research group is engaged in a wide range of interdisciplinary projects at the interface of synthetic chemistry, biochemistry, biophysics, and translational medicine. Our research focuses on the design and synthesis of novel metal complexes, characterization of photophysical properties, and the exploration of their biological activity against target proteins as well as in cancerous cells, with particular emphasis on understanding their potential for medical applications. We offer a dynamic and collaborative environment that combines expertise in chemistry, biology, physics, and medicine, providing opportunities to gain experience with cutting-edge methods. Candidates joining our team will contribute to innovative research at the forefront of medicinal chemistry and translational biophysics. Information to the activities of the research group can be found at our website (https://www.kargesgroup.ruhr-uni-bochum.de/).
Scope: part-time
Duration: fixed-term, 36 Monate
Start: at the earliest possible date or by August 01/2026
Apply by: 2026-05-11
Your tasks:
- Design and synthesize novel metal-based conjugates tailored for selective binding to target proteins, using advanced synthetic methodologies and comprehensive analytical characterization.
- Perform detailed photophysical investigations, including absorption and emission studies as well as reactive oxygen species generation, to provide insight into the photocatalytic properties and establish structure–property relationships.
- Conduct biochemical evaluation of target proteins, including expression, purification, and assessment of binding affinity.
- Plan and execute biological experiments in cancer cell models, including cytotoxicity assays, cellular uptake and localization studies, and mechanistic investigations of photoinduced cell death pathways.
- Integrate chemical, biochemical, and photophysical data to elucidate the mode of action of conjugates, with a focus on selective protein targeting and photodynamic activity.
- Document, analyze, and present research findings through reports, publications, and scientific presentations.
- Collaborate within an interdisciplinary research environment at the interface of chemistry, biology, physics, and medicine.
Your profile:
- Master of Science degree in chemistry, biochemistry, biology or a related discipline
- Experience with synthetic and spectroscopic methods
- Experience with protein expression is an advantage
- Experience with cell culture techniques is an advantage
- Ability to work independently and take initiative
- Good command of the English language
- Flexibility and adaptability
- Strong teamwork and collaboration skills
We offer:
- Challenging and varied tasks with a high degree of responsibility
- Support and collaboration with competent colleagues
- Team-oriented work in a dedicated, international, and respectful team
- A friendly and collegial working environment
Further information:
The position is salaried and based on the collective agreement of the Länder (TV-L). If the personal and collective agreement requirements are met, the employee will receive pay grade E 13 TV-L.
Further information can be found at (in German).
The place of work is Ruhr University Bochum.
The load of teaching will be calculated according to § 3 of Lehrverpflichtungsverordnung (state of North Rhine-Westphalia).
RUB sees itself as a university with an international presence. The campus languages are German and English. Competence in at least one of the two languages and the willingness to learn the other are a prerequisite. RUB provides corresponding free courses for employees.
German language courses are offered by the University Language Center (ZFA) in the field of German as a Foreign Language (DaF). https://www.daf.ruhr-uni-bochum.de/sbgk/index.html.en
The Staff Council has the right to participate in all selection interviews. At the request of a candidate (m/f/x), it will ensure its participation in the entire procedure. Please contact wpr@rub.de.
The Ruhr-Universität Bochum is one of Germany’s leading research universities, addressing the whole range of academic disciplines. A highly dynamic setting enables researchers and students to work across the traditional boundaries of academic subjects and faculties. To create knowledge networks within and beyond the university is Ruhr-Universität Bochum’s declared aim.
The Ruhr-Universität Bochum stands for diversity and equal opportunities. For this reason, we favour a working environment composed of heterogeneous teams, and seek to promote the careers of individuals who are underrepresented in our respective professional areas. The Ruhr-Universität Bochum expressly requests job applications from women. In areas in which they are underrepresented they will be given preference in the case of equivalent qualifications with male candidates. Applications from individuals with disabilities are most welcome.
Contact persons for further information:
Riccarda Aust Tel.: +49 234 32 18035
Travel costs, accommodation costs and loss of earnings or other application costs for job interviews can unfortunately not be reimbursed.
We look forward to receiving your application via our online application portal by 2026-05-11. Please make sure to mention the reference number ANR 5680.
RUHR-UNIVERSITÄT BOCHUM
44801 Bochum
Universitätsstraße 150
SOCIAL MEDIA